South Africa halts AstraZeneca vaccine rollout over new variant

South Africa halts AstraZeneca vaccine rollout over new variant

A traveller is tested for the coronavirus disease amid a nationwide COVID-19 lockdown, at the Grasmere Toll Plaza in Lenasia, South Africa, January 2021


South Africa has put its roll-out of the Oxford-AstraZeneca vaccine on hold after a study showed “disappointing” results against its new Covid variant.

Scientists say the variant accounts for 90% of new Covid cases in South Africa.

The study, involving around 2,000 people, found the vaccine offered “minimal protection” against mild and moderate cases.

But experts are hopeful that the vaccine will still be effective at preventing severe infections.

South Africa has recorded more than 1.4 million cases of coronavirus and 46,000 deaths since the pandemic began, according to data collated by Johns Hopkins University. The country has received 1m doses of the Oxford-AstraZeneca jab and was due to start vaccinating people this week.

Speaking at an online news conference on Sunday, South African Health Minister Zweli Mkhize said his government would wait for further advice on how best to proceed with the AstraZeneca vaccine in light of the findings.

  • Oxford jab offers less S Africa Covid protection
  • How worrying are the new variants?
  • South Africa coronavirus variant: What’s the risk?

In the meantime, he said, the government will offer vaccines produced by Johnson & Johnson and Pfizer in the coming weeks.

What does it mean for serious cases?

The trial was carried out by researchers at the University of the Witwatersrand in South Africa and the UK’s Oxford University, but has not yet been peer reviewed.

The trial’s chief investigator, Prof Shabir Madhi, said it showed that “unfortunately, the AstraZeneca vaccine does not work against mild and moderate illness”.

Prof Madhi said the study had not been able to investigate the vaccine’s efficacy in preventing more serious infections, as participants had an average age of 31 and so did not represent the demographic most at risk of severe symptoms from the virus.

The vaccine’s similarity to one produced by Johnson & Johnson, which was found to reduce severe disease by 89%, suggested it would still prevent serious illness, according to Prf Madhi.

“There’s still some hope that the AstraZeneca vaccine might well perform as well as the Johnson & Johnson vaccine in a different age group demographic that I address of severe disease,” he told the BBC.

Other experts were also hopeful that the vaccine remained effective at combating more serious cases.

“What we’re seeing from other vaccine developers is that they have a reduction in efficacy against some of the variant viruses and what that is looking like is that we may not be reducing the total number of cases, but there’s still protection in that case against deaths, hospitalisations and severe disease,” Prof Sarah Gilbert, Oxford’s lead vaccine developer, told the Andrew Marr Show on Sunday.

She said developers were likely to have a modified version of the injection against the South Africa variant, also known as 501.V2 or B.1.351, later this year.

Prof Tulio de Oliveira, an epidemiologist at the Nelson R Mandela School of Medicine, said he hoped the vaccine would still have a role to play in South Africa’s inoculation programme.

“Our hope is that despite the very low efficacy on a small phase two trial in South Africa on the mild infections, that we would still see some efficacy on severe infections,” he told the BBC.

Ministers in the UK have sought to reassure the public over the effectiveness of the Oxford-AstraZeneca vaccine. Vaccines Minister Nadhim Zahawi said the injection appeared to work well against dominant variants in the UK, while Health Minister Edward Argar said there was “no evidence” the vaccine was not effective at preventing severe illness.

Graphic shows how the vaccines compare

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Early results from Moderna suggest its vaccine is still effective against the South Africa variant, while AstraZeneca has said its vaccine provides good protection against the UK variant first identified in the UK.

Early results suggest the Pfizer-BioNTech vaccine protects against the new variants.

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Analysis box by Nick Triggle, health correspondent

Viruses mutate – so what is happening is not surprising.

The mutations seen in South Africa change the part of the virus that the vaccines target. It means all the vaccines that have been produced so far are likely to be affected in some way.

Trials for Novavax and Janssen vaccines that were carried out in South Africa showed less effectiveness against this variant. Both are currently before the UK regulator.

Therefore the news about Oxford-AstraZeneca does not come out of the blue.

The fact it now only has “minimal” effect according to reports is concerning – the other vaccines showed effectiveness in the region of 60% against the South African variant.

But we should be careful about rushing to judgement. The study was small so there is only limited confidence in the findings.

What is more, there is still hope the vaccine will prevent serious illness and hospitalisation.

What this once again illustrates is the pandemic is not going to end with one Big Bang. Vaccines are likely to have to change to keep pace with the virus.

Progress will be incremental. But vaccines are still the way out of this.

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What do we know about the variant?

The South Africa variant carries a mutation, called N501Y, that appears to make it more contagious or easy to spread.

However, there is no evidence that it causes more serious illness for the vast majority of people who become infected. As with the original version, the risk is highest for people who are elderly or have significant underlying health conditions.

At least 20 other countries including Austria, Norway and Japan, have found cases of the variant.

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Published at Mon, 08 Feb 2021 11:25:29 +0000

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Written by Riel Roussopoulos


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